MAT for Alcohol Use Disorder: A Comprehensive Guide

Are you or someone you know struggling with Alcohol Use Disorder (AUD)? If so, you are not alone. AUD is a common and serious condition that affects millions of people worldwide. Despite its prevalence, many individuals with AUD do not receive the treatment they need due to stigma, lack of access to care, or fear of withdrawal symptoms. If left untreated, AUD can have devastating consequences, including liver disease, depression, and even death.

Medication-Assisted Treatment (MAT) has emerged as a promising approach for managing AUD. MAT combines medication with behavioral therapies to help individuals overcome their alcohol dependence. MAT has been proven effective in reducing alcohol consumption, preventing relapse, and improving overall health.

This comprehensive guide will explore how MAT can help treat Alcohol Use Disorder. We will discuss the various medications used in MAT, how they work, and the benefits and limitations of this approach. Read until the end to find out.

Medications Used in MAT for AUD

There are several medications used in MAT for alcohol use disorder. These medications work by reducing the severity of withdrawal symptoms, decreasing cravings, and blocking the pleasurable effects of alcohol. They are often combined with behavioral therapies to provide a comprehensive treatment approach for AUD.


This medication works by causing unpleasant symptoms, such as nausea and vomiting, when an individual drinks alcohol. This can help deter individuals from drinking by creating a negative association with alcohol.


This medication works by blocking the effects of alcohol on the brain, thereby reducing the pleasurable effects of drinking. It can also help reduce cravings for alcohol.


This medication works by stabilizing the brain’s chemistry, which can help reduce cravings and prevent relapse. It is often used in combination with behavioral therapies.


This medication is an anticonvulsant that can also help reduce cravings for alcohol. It works by altering the brain’s chemistry to make alcohol less appealing.


This medication is a muscle relaxant that can also help reduce cravings for alcohol. It works by reducing anxiety and promoting relaxation, which can help individuals resist the urge to drink.

How MAT Helps Treat AUD

MAT is an evidence-based approach for managing AUD that combines medication with behavioral therapies. It works by reducing the severity of withdrawal symptoms, decreasing cravings, and blocking the pleasurable effects of alcohol, thereby making it easier for individuals to abstain from drinking.

MAT can be used for detoxification (to help individuals safely withdraw from alcohol) and maintenance (to help individuals sustain abstinence and prevent relapse).

The medications used in MAT for AUD have different mechanisms of action, but they all work to address the underlying chemical imbalances in the brain that contribute to addiction.

For example, naltrexone and acamprosate can help reduce cravings for alcohol by altering the brain’s chemistry. At the same time, disulfiram creates a negative association with alcohol by causing unpleasant symptoms when individuals drink.

MAT is not a one-size-fits-all approach, and the medication used will depend on the individual’s specific needs and medical history. Healthcare professionals will conduct a thorough assessment to determine the best course of treatment.

Benefits and Limitations of MAT for AUD


  • Improved abstinence rates
  • Reduced cravings
  • Increased retention in treatment
  • Improved overall health
  • Combination approach


  • Not a standalone treatment
  • The medications used in MAT can have side effects
  • Limited access
  • Cost
  • Risk of dependence

The Process of MAT for AUD

1. Assessment

The first step in the MAT process is a comprehensive assessment by a healthcare professional. The assessment will include a medical history, physical examination, and laboratory tests. The assessment aims to determine the severity of the addiction, identify any co-occurring mental health conditions or medical conditions, and determine the best course of treatment.

2. Medication selection

Once the assessment is complete, the healthcare professional will determine the best medication based on the individual’s needs and medical history. The medications used in MAT for AUD include naltrexone, acamprosate, and disulfiram.

3. Medication initiation

After the medication has been selected, the healthcare professional will initiate the medication at the appropriate dose. The individual may need to undergo a period of detoxification before starting MAT to withdraw from alcohol safely.

4. Medication monitoring

Once the medication has been initiated, the healthcare professional will monitor the individual’s response and adjust the dose as needed. It is essential to follow the healthcare professional’s instructions regarding medication use and to refrain from discontinuing or adjusting the dose without medical supervision.

5. Behavioral therapy

MAT for AUD is not standalone and should be combined with behavioral therapies. The healthcare professional will refer the individual to appropriate behavioral therapy programs to address the psychological aspects of addiction and develop coping skills to maintain sobriety.

6. Ongoing support

MAT is a long-term treatment approach; ongoing support is essential for maintaining sobriety and preventing relapse. The healthcare professional will provide continuous monitoring and support and may refer the individual to support groups or other community resources to provide additional support.


Medication-Assisted Treatment (MAT) for Alcohol Use Disorder (AUD) is a practical and evidence-based approach to managing addiction. MAT can improve abstinence rates, reduce cravings, increase retention in treatment, improve overall health outcomes, and provide a combination approach that addresses addiction’s physical and psychological aspects. 

However, it is important to consider both the benefits and limitations of MAT and to work with a healthcare professional to determine the best course of treatment for your specific needs. If you can’t come to visit a physical clinic, you can rely on online providers such as Confidant Health. Confidant Health has a downloadable app that provides easy access to expert help, confidential and discreet support, and resources to help you on your journey to sobriety.

Similar Articles

Most Popular